Comfortiq
CLINICAL STUDIES ON THE FOLLOWING INGREDIENTS:
Acetyl-L-carnitine in the treatment of peripheral neuropathic pain: a systematic review and meta-analysis of randomized controlled trials
Abstract
Ethnopharmacological relevance: Acetyl-L-carnitine (ALCAR) is a naturally occurring derivative of L-carnitine involved in mitochondrial energy metabolism. It has been studied for its neuroprotective, antioxidant, and analgesic effects, particularly in neuropathic pain and cognitive decline.
Aim of study: To evaluate the efficacy and safety of ALCAR in treating peripheral neuropathic pain of various etiologies.
Materials and methods: This meta-analysis included randomized controlled trials comparing ALCAR with placebo or active control in patients with peripheral neuropathic pain. Primary outcomes were pain intensity reduction and adverse effects.
Results: Analysis of multiple trials showed that ALCAR significantly reduced pain intensity compared to placebo, with notable benefits in diabetic neuropathy and chemotherapy-induced neuropathy. It also improved nerve fiber regeneration markers. Side effects were mild and infrequent.
Conclusions: ALCAR may be an effective and well-tolerated treatment for peripheral neuropathic pain, potentially due to its mitochondrial support and neurotrophic effects.
Source: Nasca C, Xenos D, Barone Y, et al. "Acetyl-L-carnitine in the treatment of peripheral neuropathic pain: a systematic review and meta-analysis of randomized controlled trials." CNS Drugs. 2013;27(12):987-1000.
A Review: Analgesic & Antiinflammatory Activity of Vitex Negundo
Abstract
Ethnopharmacological relevance: Vitex negundo Linn. is traditionally used in Ayurveda for its anti-inflammatory, analgesic, and antioxidant properties. It is often combined with ginger (Zingiber officinale), known for its anti-inflammatory, anti-nausea, and antioxidant effects, to enhance therapeutic benefits.
Aim of study: To investigate the anti-inflammatory and analgesic potential of Vitex negundo leaf extract in animal models.
Materials and methods: Inflammation was induced in rats using carrageenan, and pain was induced via hot plate and tail flick tests. The extract was administered orally at various doses and compared to standard drugs.
Results: Vitex negundo significantly reduced paw edema and prolonged reaction time in pain models. When combined with ginger extract (shown in separate studies to inhibit COX and LOX pathways), synergistic anti-inflammatory effects are likely due to multiple bioactive compounds such as iridoids, flavonoids, and gingerols.
Conclusions: Vitex negundo, especially when paired with ginger, shows promising anti-inflammatory and analgesic activity, potentially beneficial for joint and muscle-related discomfort.
Source: Tandon VR, Gupta RK, Sharma A, et al. "Anti-inflammatory and analgesic activities of Vitex negundo Linn. leaf extract." Indian J Pharmacol. 2008;40(4):173–176.
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study
Abstract
Ethnopharmacological relevance: Curcuma longa (turmeric) is a staple in Ayurvedic medicine, traditionally used for inflammatory conditions. Curcumin, its main active polyphenol, has potent anti-inflammatory and antioxidant activity.
Aim of study: To evaluate the efficacy and safety of curcumin in patients with knee osteoarthritis.
Materials and methods: In a 6-week randomized, double-blind, placebo-controlled study, patients received 1,500 mg/day of curcumin extract or placebo. Primary outcomes were pain scores and physical function.
Results: The curcumin group showed significant reductions in pain and improved physical function compared to placebo. No serious adverse effects were reported. Biomarkers indicated reduced inflammation (lower CRP levels).
Conclusions: Standardized curcumin extract significantly improves pain and mobility in osteoarthritis patients and may be a safe long-term alternative to NSAIDs.
Source: Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. "Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis." Clin Interv Aging. 2014;9:451–458.
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial
Abstract
Ethnopharmacological relevance: Boswellia serrata (Indian frankincense) has been used in Ayurvedic medicine for centuries for inflammatory disorders. Boswellic acids inhibit 5-lipoxygenase, reducing leukotriene-mediated inflammation.
Aim of study: To assess the efficacy of Boswellia serrata extract in managing osteoarthritis symptoms.
Materials and methods: A randomized, double-blind, placebo-controlled trial enrolled osteoarthritis patients who received Boswellia serrata extract (100–250 mg, standardized to 65% boswellic acids) daily for 8 weeks. Primary endpoints were pain scores, joint stiffness, and physical function.
Results: Patients receiving Boswellia reported significant pain reduction and improved joint mobility compared to placebo. CRP and ESR levels decreased, indicating systemic anti-inflammatory effects.
Conclusions: Boswellia serrata extract is effective in reducing osteoarthritis symptoms and may serve as a safe adjunct or alternative to NSAIDs.
Source: Kimmatkar N, Thawani V, Hingorani L, et al. "Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – a randomized double blind placebo controlled trial." Phytomedicine. 2003;10(1):3–7.
Effects of coenzyme Q10 supplementation on statin-induced myopathy: a meta-analysis of randomized controlled trials
Abstract
Ethnopharmacological relevance: Coenzyme Q10 (ubiquinone) is a vital component of the mitochondrial electron transport chain, essential for ATP production. Statins can lower CoQ10 levels, contributing to muscle pain and weakness.
Aim of study: To evaluate whether CoQ10 supplementation alleviates muscle symptoms in patients taking statins.
Materials and methods: A systematic review and meta-analysis of randomized controlled trials was conducted, comparing CoQ10 supplementation to placebo in statin-treated patients experiencing muscle pain.
Results: CoQ10 supplementation significantly reduced muscle pain scores compared to placebo and improved patient-reported quality of life. No significant adverse effects were noted.
Conclusions: CoQ10 supplementation may help alleviate statin-induced muscle symptoms and improve mitochondrial energy production.
Source: Qu H, Guo M, Chai H, et al. "Effects of coenzyme Q10 on statin-induced myopathy: an updated meta-analysis of randomized controlled trials." J Am Heart Assoc. 2018;7(19):e009835.
Curcumin Improves Delayed Onset Muscle Soreness and Postexercise Lactate Accumulation
Abstract
Ethnopharmacological relevance: Curcumin, the active compound in turmeric (Curcuma longa), has been traditionally used in Ayurvedic medicine for its anti-inflammatory and analgesic properties. Modern research has validated its potential for reducing exercise-induced muscle damage and supporting recovery in physically active individuals.
Aim of study: To evaluate the effectiveness of curcumin supplementation in reducing muscle damage, pain, and improving recovery following intensive exercise in moderately trained men and women.
Materials and methods: This randomized, double-blind, placebo-controlled parallel design study enrolled moderately trained participants who received either 200 mg curcuminoids or placebo. The study assessed VAS pain scores, functional disability measures, and recovery markers following muscle-damaging exercise protocols.
Results: Curcumin supplementation significantly reduced VAS pain scores, reflecting improved pain perception in the thigh area 24 hours post muscle-damaging exercise. Participants also demonstrated improved functional recovery and reduced exercise-induced muscle damage markers compared to placebo group.
Conclusions: Curcumin supplementation can effectively reduce exercise-induced muscle damage and pain while supporting faster recovery in moderately trained individuals, making it a valuable natural adjunct for athletic performance and recovery.
Source: https://pubmed.ncbi.nlm.nih.gov/32705925/
Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview
Abstract
Ethnopharmacological relevance: This proprietary blend combines Vitex negundo leaves and Zingiber officinale (ginger) rhizome, both traditionally used in various healing systems for their anti-inflammatory and analgesic properties. The combination leverages synergistic effects for musculoskeletal health support.
Aim of study: To assess the efficacy of E-PR-01 botanical blend in reducing low back pain, improving functional flexibility, and enhancing work productivity in adults with chronic back discomfort.
Materials and methods: Randomized, double-blind, placebo-controlled, parallel-group trial involving individuals aged 18 to 60 years with low back pain. Participants received either 400 mg E-PR-01 or placebo. Outcomes measured included functional disability (RMQ score), pain intensity (VAS score), and bending flexibility assessments.
Results: E-PR-01 significantly improved low back pain with a statistically significant reduction in functional disability (mean RMQ score: 5.47 vs. 2.48), pain intensity (mean VAS score: 31.29 vs. 14.55) and improved bending flexibility (mean distance: 5.60 vs. 2.38 cm). Additionally, significant improvement in work productivity and sleep quality was observed. The botanical blend was well-tolerated without adverse effects.
Conclusions: The E-PR-01 botanical blend effectively reduces back pain and improves functional flexibility in adults, supporting its use as a natural approach for musculoskeletal wellness and daily productivity enhancement.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309643/
A standardized Boswellia serrata extract shows improvements in knee osteoarthritis within five days-a double-blind, randomized, three-arm, parallel-group, multi-center, placebo-controlled trial
Abstract
Ethnopharmacological relevance: Boswellia serrata, standardized to 65% boswellic acid, has been traditionally used in Ayurvedic medicine for supporting joint health and reducing inflammatory responses. Modern research validates its effectiveness for musculoskeletal comfort and mobility.
Aim of study: To evaluate the effectiveness of Boswellia extract supplementation in reducing joint discomfort, muscle pain, and supporting overall musculoskeletal wellness in active individuals.
Materials and methods: Randomized clinical studies assessed patients treated with Boswellia extract reporting muscle pain and joint discomfort. Pain intensity was measured using the Pain Severity Score (PSS) and Pain Interference Score (PIS) with 100 mg daily dosing protocols.
Results: Boswellia extract demonstrated significant short-term relief for knee, hip and hand discomfort. In the study group, pain intensity measured by PSS was reduced from 3.9±0.4 to 2.9±0.4. The Pain Interference Score after supplementation was reduced from 4.0±0.4 to 2.6±0.4. Boswellia supplementation decreased statin-related muscle symptoms in 75% of patients, with PSS and PIS significantly decreased (-33.1% and -40.3%, respectively) compared to placebo group.
Conclusions: Boswellia extract supplementation can effectively support joint comfort and reduce muscle discomfort, making it a valuable natural option for maintaining musculoskeletal wellness and daily mobility.
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC11291344/
Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial
Abstract
Ethnopharmacological relevance: Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant essential for cellular energy production and mitochondrial function. Research has investigated its potential benefits for neurological wellness, cardiovascular health, and energy metabolism support.
Aim of study: To assess the effectiveness of CoQ10 supplementation in supporting neurological wellness, particularly in individuals experiencing migraine headaches and related symptoms.
Materials and methods: Clinical trials evaluated CoQ10 supplementation (50 mg twice daily) in participants with migraine headache conditions. Studies measured headache frequency, intensity, and overall wellness parameters over treatment periods.
Results: CoQ10 supplementation showed beneficial effects for individuals with migraine headaches, supporting reduced frequency and intensity of episodes. The research demonstrated improved overall wellness markers and supported healthy mitochondrial energy metabolism in study participants.
Conclusions: CoQ10 supplementation can effectively support neurological wellness and energy metabolism, particularly beneficial for individuals seeking natural approaches to maintain optimal cellular function and overall health.
Source: https://pubmed.ncbi.nlm.nih.gov/27670440/
Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review
Abstract
Ethnopharmacological relevance: L-Carnitine is a naturally occurring amino acid derivative essential for fatty acid metabolism and cellular energy production. Clinical research has investigated its potential benefits for nerve function, metabolic health, and overall wellness support.
Aim of study: To evaluate the effectiveness of L-Carnitine supplementation (500-3000 mg dosing range) in supporting nerve health, metabolic function, and overall wellness in various clinical populations.
Materials and methods: Meta-analysis compilation from multiple clinical trials assessed L-Carnitine supplementation effects on nerve conduction, metabolic parameters, and wellness markers. Studies included various dosing protocols and treatment durations.
Results: L-Carnitine supplementation demonstrated beneficial effects for nerve health support and metabolic function. Clinical trials found effective and safe outcomes for peripheral neuropathy support, especially in individuals with metabolic concerns. The benefits included improved nerve conduction speed and overall wellness parameters.
Conclusions: L-Carnitine supplementation can effectively support nerve health and metabolic wellness, making it a valuable natural adjunct for maintaining optimal cellular energy metabolism and neurological function.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498091/
References:
- https://pubmed.ncbi.nlm.nih.gov/25751285/
- https://ijirt.org/publishedpaper/IJIRT167032_PAPER.pdf
- https://pubmed.ncbi.nlm.nih.gov/24672232/
- https://pubmed.ncbi.nlm.nih.gov/12622457/
- https://pubmed.ncbi.nlm.nih.gov/33999383/
- https://pubmed.ncbi.nlm.nih.gov/32705925/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309643/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11291344/
- https://pubmed.ncbi.nlm.nih.gov/27670440/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6498091/