Lycopene
CLINICAL STUDIES ON THE FOLLOWING INGREDIENTS:
LYCOPENE – A BIOACTIVE CAROTENOID OFFERING MULTIPLE HEALTH BENEFITS: A REVIEW
Abstract
Lycopene, a red tomato pigment, is linked to reduced risk of chronic diseases. Clinical research confirms its protective effects on the cardiovascular system, including lowering myocardial infarction risk, reducing blood pressure, and preventing LDL oxidation. High blood lycopene is associated with lower risks of prostate, lung, uterine, and breast cancer. Lycopene inhibits cancer cell proliferation, induces apoptosis, and prevents metastasis, mainly due to its antioxidant properties. It also benefits skeletal and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s.
Source: https://onlinelibrary.wiley.com/doi/10.1111/ijfs.14260
LYCOPENE AS A NATURAL ANTIOXIDANT USED TO PREVENT HUMAN HEALTH DISORDERS
Abstract
Lycopene, a potent antioxidant found in tomatoes, is effective against cancer, diabetes, cardiac complications, oxidative stress, inflammation, skin and bone diseases, hepatic, neural, and reproductive disorders. The review summarizes its sources, biochemistry, mechanisms of action, and potential as a nutraceutical for lifestyle-related disorders, as well as its safety profile.
Source: https://www.mdpi.com/2076-3921/9/8/706
LYCOPENE IN PROTECTION AGAINST OBESITY AND DIABETES: A MECHANISTIC REVIEW
Abstract
Lycopene, mainly from tomatoes, shows protective effects against obesity and diabetes in various organs. Its mechanisms include antioxidant and anti-inflammatory actions, and regulation of signaling pathways such as AGE/RAGE, JNK/MAPK, PI3K/Akt, and SIRT1/FoxO1/PPARγ. Epidemiological studies support lycopene’s role in lowering obesity and diabetes risk. Cis-isomers are more bioavailable than trans-lycopene. Lycopene is safe and can be sourced from plants, synthesis, or fermentation.
Source: https://pubmed.ncbi.nlm.nih.gov/32535223/
LYCOPENE AND VASCULAR HEALTH
Abstract
Lycopene, found in red fruits and vegetables, may improve vascular function and help prevent cardiovascular disorders. Its activities include antiatherosclerotic, antioxidant, anti-inflammatory, antihypertensive, antiplatelet, anti-apoptotic, and endothelial protective effects. Lycopene improves metabolic profiles and reduces arterial stiffness, benefiting patients with atherosclerosis, metabolic syndrome, hypertension, and other vascular diseases, though some results are inconsistent.
Source: https://www.frontiersin.org/articles/10.3389/fphar.2018.00521/full
CAN LYCOPENE BE CONSIDERED AN EFFECTIVE PROTECTION AGAINST CARDIOVASCULAR DISEASE?
Abstract
Lycopene, mainly from tomatoes, has the highest antioxidant potential among carotenoids. Evidence suggests lycopene benefits cardiovascular health, particularly in preventing atherosclerosis and other cardiovascular diseases. Despite some contradictory findings due to study differences, increasing lycopene-rich food intake may positively impact cardiovascular disease, especially in high-risk populations.
LYCOPENE: FOOD SOURCES, BIOLOGICAL ACTIVITIES, AND HUMAN HEALTH BENEFITS
Abstract
Lycopene, abundant in tomatoes, prevents fat autoxidation and is linked to positive health effects. It plays a role in reducing atherosclerosis risk by affecting serum lipid levels, endothelial function, inflammation, blood pressure, and antioxidative potential. Lycopene’s antioxidant properties may also enhance food preservation and nutritional value.
Source: https://www.hindawi.com/journals/omcl/2021/2713511/
LET FOOD BE YOUR MEDICINE: NUTRACEUTICAL PROPERTIES OF LYCOPENE
Abstract
Lycopene, a carotenoid responsible for the red color in fruits and vegetables, has strong antioxidant properties. It is reported to have nutraceutical effects in cancer, infertility, metabolic syndrome, and liver damage. Supplementation may serve as a causative treatment for these diseases, with clinical trials supporting its health impact.
Source: https://pubmed.ncbi.nlm.nih.gov/31120074/
A REVIEW FOR THE PHARMACOLOGICAL EFFECT OF LYCOPENE IN CENTRAL NERVOUS SYSTEM DISORDERS
Abstract
Lycopene, from tomatoes and other red fruits, shows prophylactic and therapeutic effects in CNS disorders such as Alzheimer’s, Parkinson’s, Huntington’s, cerebral ischemia, epilepsy, and depression. It improves cognition and memory in animal models and protects against neurotoxicities. Mechanisms include inhibition of oxidative stress, neuroinflammation, neuronal apoptosis, and restoration of mitochondrial function.
Source: https://pubmed.ncbi.nlm.nih.gov/30616078/
LYCOPENE: A NATURAL ARSENAL IN THE WAR AGAINST OXIDATIVE STRESS AND CARDIOVASCULAR DISEASES
Abstract
Lycopene, a red pigment in many fruits, is a potent antioxidant that combats reactive oxygen species. It helps prevent chronic diseases, including diabetes, neurodegenerative, and cardiovascular diseases. Lycopene reduces blood pressure by inhibiting angiotensin-converting enzyme and regulating nitric oxide, lowers LDL, and improves HDL, thus protecting against coronary artery disease and hypertension.
Source: https://www.mdpi.com/2076-3921/11/2/232
LYCOPENE: A CRITICAL REVIEW OF DIGESTION, ABSORPTION, METABOLISM, AND EXCRETION
Abstract
Lycopene, a non-provitamin A carotenoid, is linked to reduced risk of chronic diseases. Its health effects depend on digestion, absorption, metabolism, and excretion, influenced by genetic and dietary factors. Most lycopene is cleaved by BCO2 enzyme. Further research is needed on its metabolism and optimal dietary strategies to enhance bioavailability.
Source: https://pubmed.ncbi.nlm.nih.gov/33668703/
THE ANTI-CANCER ACTIVITY OF LYCOPENE: A SYSTEMATIC REVIEW OF HUMAN AND ANIMAL STUDIES
Abstract
A systematic review of 72 studies confirms lycopene’s anti-cancer activities, especially in prostate cancer. Mechanisms include regulation of oxidative and inflammatory processes, induction of apoptosis, and inhibition of cell division, angiogenesis, and metastasis. The effectiveness may depend on tumor location and lycopene storage capacity.
Source: https://www.mdpi.com/2072-6643/14/12/2472
PROTECTIVE EFFECTS OF LYCOPENE IN CANCER, CARDIOVASCULAR, AND NEURODEGENERATIVE DISEASES
Abstract
Recent studies show lycopene reduces risk and complications of chronic diseases like cardiovascular disease, obesity, type 2 diabetes, cancer, and neurodegenerative disorders. Lycopene’s antioxidant properties help alleviate inflammation and oxidative stress, modulate transcription factors, and enhance neuroprotection.
Source: https://pubmed.ncbi.nlm.nih.gov/32126272/
LYCOPENE: A POTENT ANTIOXIDANT FOR THE AMELIORATION OF TYPE II DIABETES MELLITUS
Abstract
Lycopene, found in tomatoes and red fruits, has antioxidant properties that help manage type II diabetes mellitus. It scavenges reactive species and reduces oxidative stress, improving glycemic control and oxidative stress biomarkers in animal and human studies.
Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC9000630/
POTENTIAL INHIBITORY EFFECT OF LYCOPENE ON PROSTATE CANCER
Abstract
Lycopene, a dietary carotenoid, has anti-cancer, anti-proliferative, and apoptotic effects on prostate cancer. It suppresses cancer progression, arrests the cell cycle, and induces apoptosis in both in vivo and in vitro studies. Lycopene modulates signaling pathways involved in cancer prevention and treatment.
Source: https://pubmed.ncbi.nlm.nih.gov/32768949/
NEW INSIGHTS INTO MOLECULAR MECHANISM BEHIND ANTI-CANCER ACTIVITIES OF LYCOPENE
Abstract
Lycopene, commonly found in tomatoes, is associated with reduced cancer risk, especially prostate and lung cancer. Its anti-cancer activity involves suppression of oncogene expression, induction of proapoptotic pathways, resolution of inflammation, and modulation of immune cells to suppress tumor growth and progression.
Source: https://pubmed.ncbi.nlm.nih.gov/34202203/
References:
- https://onlinelibrary.wiley.com/doi/10.1111/ijfs.14260
- https://www.mdpi.com/2076-3921/9/8/706
- https://pubmed.ncbi.nlm.nih.gov/32535223/
- https://www.frontiersin.org/articles/10.3389/fphar.2018.00521/full
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8880080/
- https://www.hindawi.com/journals/omcl/2021/2713511/
- https://pubmed.ncbi.nlm.nih.gov/31120074/
- https://pubmed.ncbi.nlm.nih.gov/30616078/
- https://www.mdpi.com/2076-3921/11/2/232
- https://pubmed.ncbi.nlm.nih.gov/33668703/
- https://www.mdpi.com/2072-6643/14/12/2472
- https://pubmed.ncbi.nlm.nih.gov/32126272/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9000630/
- https://pubmed.ncbi.nlm.nih.gov/32768949/
- https://pubmed.ncbi.nlm.nih.gov/34202203/